Lai-Hua Xie Selected Research

sarcolipin

1/2021	Sarcolipin haploinsufficiency prevents dystrophic cardiomyopathy in mdx mice.
10/2019	Sarcolipin overexpression impairs myogenic differentiation in Duchenne muscular dystrophy.
10/2017	Reducing sarcolipin expression mitigates Duchenne muscular dystrophy and associated cardiomyopathy in mice.
6/2012	Ablation of sarcolipin results in atrial remodeling.
2/2011	Ablation of phospholamban and sarcolipin results in cardiac hypertrophy and decreased cardiac contractility.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Lai-Hua Xie Research Topics

Disease

7	Cardiac Arrhythmias (Arrythmia) 01/2021 - 08/2007
7	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 01/2021 - 01/2013
5	Cardiomyopathies (Cardiomyopathy) 01/2021 - 10/2017
4	Iron Overload 08/2020 - 11/2013
4	Melanoma (Melanoma, Malignant) 07/2017 - 07/2010
4	Ischemia 03/2017 - 09/2015
3	Heart Failure 07/2021 - 02/2011
3	Muscular Dystrophies (Muscular Dystrophy) 10/2019 - 08/2015
3	Hypoxia (Hypoxemia) 03/2017 - 09/2015
2	Hemochromatosis (Bronze Diabetes) 08/2020 - 01/2018
2	Fibrosis (Cirrhosis) 01/2018 - 06/2012
2	Atrial Remodeling 01/2014 - 06/2012
2	Cardiomegaly (Heart Hypertrophy) 02/2013 - 02/2011
1	Chronic Disease (Chronic Diseases) 01/2021
1	Cardiac Sudden Death (Sudden Cardiac Arrest) 01/2021
1	Heart Diseases (Heart Disease) 01/2020
1	Neoplasms (Cancer) 01/2019
1	Myocardial Infarction 01/2019
1	Ventricular Premature Complexes (Premature Ventricular Contraction) 01/2018
1	Ventricular Fibrillation 01/2018
1	Anemia 01/2018
1	Sickle Cell Anemia (Hemoglobin S Disease) 01/2018
1	Thalassemia 01/2018
1	Hypertrophy 12/2017
1	Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain) 09/2015
1	Inflammation (Inflammations) 09/2015
1	Cerebral Infarction 09/2015
1	Stroke (Strokes) 11/2013
1	Sleep Initiation and Maintenance Disorders (Insomnia) 01/2013
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2012
1	Hypokalemia 08/2010
1	Neoplasm Metastasis (Metastasis) 07/2010
1	Ventricular Tachycardia 01/2008

Drug/Important Bio-Agent (IBA)

6	Connexin 43 (Connexin43)IBA 01/2020 - 08/2015
5	CalciumIBA 07/2021 - 01/2008
5	sarcolipinIBA 01/2021 - 02/2011
4	Proteins (Proteins, Gene)FDA Link 01/2019 - 07/2010
3	AntioxidantsIBA 01/2021 - 01/2018
3	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 01/2021 - 01/2018
3	Adenosine Triphosphatases (ATPase)IBA 01/2021 - 02/2011
3	Isoproterenol (Isoprenaline)FDA LinkGeneric 01/2018 - 08/2015
3	Glucose (Dextrose)FDA LinkGeneric 03/2017 - 09/2015
2	CatalaseIBA 01/2021 - 01/2018
2	Mitochondrial Permeability Transition PoreIBA 08/2020 - 12/2016
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018 - 01/2014
2	IronIBA 01/2018 - 01/2018
2	Ion Channels (Ion Channel)IBA 01/2018 - 08/2010
2	Chelating AgentsIBA 01/2018 - 09/2015
2	Oxygen (Dioxygen)IBA 01/2016 - 09/2015
2	DystrophinIBA 08/2015 - 01/2013
2	erythromycin propionate-N-acetylcysteinateIBA 06/2011 - 07/2010
2	phospholambanIBA 02/2011 - 08/2007
1	Adenosine Triphosphate (ATP)IBA 01/2021
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 08/2020
1	ConnexinsIBA 01/2020
1	Phosphotransferases (Kinase)IBA 01/2019
1	Staphylococcal Protein A (Protein A)IBA 01/2019
1	salicylhydroxamic acid (SHAM)IBA 01/2018
1	Calcium Channel Blockers (Blockers, Calcium Channel)IBA 01/2018
1	T-Type Calcium Channels (T-Type Calcium Channel)IBA 01/2018
1	Angiotensin IIIBA 12/2017
1	Calcium-Transporting ATPases (Ca2+ ATPase)IBA 10/2017
1	CationsIBA 07/2017
1	pyrazoleIBA 07/2017
1	Dithionite (Sodium Dithionite)IBA 03/2017
1	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone (FCCP)IBA 12/2016
1	Cyclophilins (Cyclophilin)IBA 12/2016
1	ZincIBA 09/2015
1	Interleukin-6 (Interleukin 6)IBA 09/2015
1	N,N,N',N'- tetrakis(2- pyridylmethyl)ethylenediamineIBA 09/2015
1	Protein Isoforms (Isoforms)IBA 01/2014
1	Phenylephrine (Neo-Synephrine)FDA LinkGeneric 02/2013
1	Cysteine (L-Cysteine)FDA Link 02/2013
1	Histone Deacetylases (Histone Deacetylase)IBA 02/2013
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2013
1	Arginine (L-Arginine)FDA Link 01/2013
1	AcidsIBA 01/2013
1	3,4,5-trimethoxycinnamic acidIBA 01/2013
1	CollagenIBA 06/2012
1	Extracellular Matrix ProteinsIBA 06/2012
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2012
1	Anti-Arrhythmia AgentsIBA 01/2012
1	Methyl ester 1,4- dihydro- 2,6- dimethyl- 5- nitro- 4- (2- (trifluoromethyl)phenyl)- 3-Pyridinecarboxylic acidIBA 08/2010
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 08/2010
1	Cyclic AMP (AMP, Cyclic)IBA 07/2010
1	Heparitin Sulfate (Heparan Sulfate)IBA 07/2010
1	Messenger RNA (mRNA)IBA 07/2010
1	Small Interfering RNA (siRNA)IBA 07/2010
1	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 08/2007
1	Pertussis ToxinIBA 08/2007

Therapy/Procedure

3	Blood Transfusion (Blood Transfusions) 08/2020 - 11/2013
1	Therapeutics 01/2018
1	Induced Hypothermia 01/2018
1	Chinese Traditional Medicine (Traditional Chinese Medicine) 01/2013
1	Oral Administration 01/2013